Dataset

• Filtered mutation lists for 20 tumor types used in MAPS paper:

  

• driverMAPS run results for the 20 tumor types used in paper:

  Note these are direct output files from the driverMAPS software, we further filtered the significant genes to remove false positives due to mutation calling errors. See below and also the paper for details.

  

• Blacklist file used after getting significant gene lists:

  For all significant genes identified for each tumor type and methods (only methods with reasonable FDR control, see reference for details) we manually performed read alignment based on bam files deposited in GDC, and generated this blacklist file with false genes. The comparisons shown in Figure 4 of in the reference were filtered by this blacklist file.

• Simulated mutation dataset:

  

  In this dataset, the files simulated_OG_genes.txt and simulated_TSG_genes.txt are genes chosen under postive selection under the OG and TSG model, respectively. These genes include genes used as training sets in driverMAPS and 200 randomly selected genes. To ensure a fair comparison with other software, we exclude the training genes when performing evaluations.

• Source data associated with the paper:

  Download source data for Figure 6c,6d and Supplementary figure 6 and 7 here.

driverMAPS software

Latest version: 1.0.5

• Version 1.0.5:

• Version 1.0.4:

• Version 1.0.3:

• Version 1.0.2:

• Version 1.0.1:

• Version 1.0.0: